Maleimide PEG Hydroxyl

产品代号：

MAL-PEG-OH

产品纯度：

≥ 95%

包装规格：

1g, 10g, 100g等（特殊包装需收取分装费用）

分子量：

2000 Da,3500 Da, 5000 Da, 7500 Da等

如需其他分子量，请联系 sales@jenkem.com 或 010-62983737

产品咨询

产品描述

参考文献

　　键凯科技提供高品质马来酰亚胺基聚乙二醇羟基产品，产品取代率≥95%。

　　键凯科技生产的异双功能马来酰亚胺PEG羟基产品通常用作两种不同化学物质的交联剂或间隔物。此异功能PEG衍生物中的PEG部分可提供水溶性、生物相容性及柔性。此产品专门应用于抗体偶联药物(ADC’s)的开发。

　　键凯科技提供MAL-PEG-OH分子量2000 Da,3500 Da, 5000 Da, 7500 Da的产品1克和10克包装。

　　键凯科技提供分装服务，需要收取分装费用，如果您需要分装为其他规格请与我们联系。

　　键凯科技同时提供其他分子量的MAL-PEG-OH衍生物产品，如你需要请与我司sales@jenkem.com联系。

　　键凯科技提供大批量生产产品及GMP级别产品，如需报价请与我们联系。

　　References:

　　1. Xu, X., et al., Efficient and targeted drug/siRNA co-delivery mediated by reversibly crosslinked polymersomes toward anti-inflammatory treatment of ulcerative colitis (UC), Nano Research, 2019, 1-9.

　　2. Mozhi, A., et al., Nrp-1 receptor targeting peptide-functionalized TPGS micellar nanosystems to deliver 10-hydroxycampothecin for enhanced cancer chemotherapy, International Journal of Pharmaceutics, 2018, 547(1–2), P. 582-592.

　　3. Sarmanova, O.E., et al., A method for optical imaging and monitoring of the excretion of fluorescent nanocomposites from the body using artificial neural networks, Nanomedicine: Nanotechnology, Biology and Medicine, 2018, 14(4), pp.1371-1380.

　　4. Fang, Z., et al., Targeted osteosarcoma chemotherapy using RGD peptide-installed doxorubicin-loaded biodegradable polymeric micelle, Biomedicine & Pharmacotherapy, 2017, V. 85, P. 160-168.

　　5. Wang, Y., et al., Quantum-Dot-Based Theranostic Micelles Conjugated with an Anti-EGFR Nanobody for Triple-Negative Breast Cancer Therapy, ACS applied materials & interfaces, 2017, 9(36):30297-305.

　　6. Mondal, G., et al., EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer, Biomacromolecules, 2016, 17 (1), pp 301–313.

　　7. Li, C., et al., Design, preparation and characterization of cyclic RGDfK peptide modified poly (ethylene glycol)-block-poly (lactic acid) micelle for targeted delivery, Materials Science and Engineering: C, 2016.

　　8. Gu, D., et al., Amphiphilic core cross-linked star polymers as water-soluble, biocompatible and biodegradable unimolecular carriers for hydrophobic drugs, Polym. Chem., 2015, 6, 6475-6487.

　　9. Prabhakar, N., et al., Functionalization of graphene oxide nanostructures improves photoluminescence and facilitates their use as optical probes in preclinical imaging, Nanoscale, 2015, 7, 10410-10420.

　　10. Ding, G.-B., et al., Integrin αVβ3-Targeted Magnetic Nanohybrids with Enhanced Antitumor Efficacy, Cell Cycle Arrest Ability, and Encouraging Anti-Cell-Migration Activity, ACS Appl. Mater. Interfaces, 2014, 6 (19), p: 16643–16652.

　　11. Song, W., et al., Anti-tumor efficacy of c(RGDfK)-decorated polypeptide-based micelles co-loaded with docetaxel and cisplatin. Biomaterials, 2014, 35(9): p. 3005-3014.

　　12. Liu, J., et al., Effect of site-specific PEGylation on the fibrinolytic activity, immunogenicity, and pharmacokinetics of staphylokinase, Acta Biochim Biophys Sin, 2014, 46 (9): 782-791.

　　13. Li, Y., et al., Docetaxel-Encapsulating Small-Sized Polymeric Micelles with Higher Permeability and Its Efficacy on the Orthotopic Transplantation Model of Pancreatic Ductal Adenocarcinoma, Int. J. Mol. Sci., 2014, 15(12), 23571-23588.

　　14. Pridgen, E. M., et al., Transepithelial Transport of Fc -Targeted Nanoparticles by the Neonatal Fc Receptor for Oral Delivery, Sci Transl Med., 2013, 5(213).

　　15. Shen, J., et al., Poly(ethylene glycol)-block-poly(d,l-lactide acid) micelles anchored with angiopep-2 for brain-targeting delivery, Journal of Drug Targeting, 2011, 19:3.

　　16. Zhan, C., et al., Loop 2 of Ophiophagus hannah Toxin b Binds with Neuronal Nicotinic Acetylcholine Receptors and Enhances Intracranial Drug Delivery, Mol. Pharmaceutics, 2010, 7(6), p: 1940–1947.

　　17. Zhan, C., et al., Cyclic RGD conjugated poly(ethylene glycol)-co-poly(lactic acid) micelle enhances paclitaxel anti-glioblastoma effect, Journal of Controlled Release, 2010, 143:1, P. 136-142.

18.Dogan, A. Leveraging thermodynamic interactions to enhance drug delivery. Diss. Case Western Reserve University, 2021.

19.Fan, N., et al., Preparation of an HI-6-loaded brain-targeted liposomes based on the nasal delivery route and the evaluation of its reactivation of central toxic acetylcholinesterase, European Journal of Pharmaceutical Sciences, 184, 2023.

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