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Hydroxyl PEG Amine, HCl Salt

产品代号:

HO-PEG-NH2HCl

产品纯度:

≥ 95%

包装规格:

1g, 10g, 100g等(特殊包装需收取分装费用)

分子量:

1000 Da,2000 Da,3500 Da, 5000 Da, 7500 Da,10000 Da, 20000 Da,等

产品咨询:

科研客户小批量一键采购地址(小于5克)

  • 产品描述
  • 参考文献
  •   键凯科技提供高品质羟基聚乙二醇胺盐酸盐产品,产品取代率大于等于95%。

      键凯科技生产的异双功能羟基PEG胺产品通常用作两种不同化学物质的交联剂或间隔物。此异功能PEG衍生物中的PEG部分可提供水溶性、生物相容性及柔性。此产品专门应用于抗体偶联药物(ADC’s)的开发。

      键凯科技提供HO-PEG-NH2HCl分子量1000 Da,2000 Da,3500 Da, 5000 Da, 7500 Da,10000 Da, 20000 Da的产品1克和10克包装。

      键凯科技提供分装服务,需要收取分装费用,如果您需要分装为其他规格请与我们联系。

      键凯科技同时提供其他分子量的HO-PEG-NH2HCl衍生物产品,如你需要请与我司sales@jenkem.com联系。

      键凯科技提供大批量生产产品及GMP级别产品,如需报价请与我们联系。

     

  •   References:

      1. Xu, Y., et al., Triphenylphosphonium-modified poly (ethylene glycol)-poly (ε-caprolactone) micelles for mitochondria-targeted gambogic acid delivery, International Journal of Pharmaceutics, 2017, 522(1):21-33.

      2. Lu, L., et al., Anisamide-Decorated pH-Sensitive Degradable Chimaeric Polymersomes Mediate Potent and Targeted Protein Delivery to Lung Cancer Cells, Biomacromolecules, 2015.

      3. Hoang, N.B.,Polymeric micelles as a diagnostic tool for image-guided drug delivery and radiotherapy of HER2 overexpressing breast cancer, Diss. University of Toronto, 2014.

      4. Hoang, B., et al., Active Targeting of Block Copolymer Micelles with Trastuzumab Fab Fragments and Nuclear Localization Signal Leads to Increased Tumor Uptake and Nuclear Localization in HER2-Overexpressing Xenografts, Mol. Pharmaceutics, 2013, 10(11), p: 4229–4241.

      5. Yang, Z., et al., Targeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modified lipid–polymer hybrid nanoparticles, Biomed. Mater., 2013, 8 025012.

      6. Felber, A.E., et al., Non-Viral Strategies for Nucleic Acid Delivery, Diss. ETH no. 21061, 2013.

      7. Bosnjakovic, A., et al., A dendrimer-based immunosensor for improved capture and detection of tumor necrosis factor-α cytokine. Analytica Chimica Acta, 2012, 720(0): p. 118-125.

      8. Hoang, B., et al., Block Copolymer Micelles Target Auger Electron Radiotherapy to the Nucleus of HER2-Positive Breast Cancer Cells, Biomacromolecules, 2012, 13(2), pp 455–465.

      9. Chen, J., et al., PLLA-PEG-TCH-labeled bioactive molecule nanofibers for tissue engineering, International Journal of Nanomedicine, 2011, 6 2533–2542.

      10. Felber, A.E., et al., siRNA nanocarriers based on methacrylic acid copolymers, Journal of Controlled Release, 2011, 152:1, P. 159-167.

      11. Lee, H., et al., The Effects of Particle Size and Molecular Targeting on the Intratumoral and Subcellular Distribution of Polymeric Nanoparticles, Molecular Pharmaceutics, 2010, 7 (4), 1195-1208.

      12. Zhou, S., Multifunctional Electrospun Nanofibers Incorporated with an Anti-infection Drug and Immobilized with Proteins, University of Manitoba, 2010.

      13. Elliott, J.A., Targeted Drug Delivery with PEGylated Immuno-Niosomes, 25th Southern Biomedical Engineering Conference, 2009, p. 363-366.

      14. Hoang, B., et al., Noninvasive Monitoring of the Fate of 111In-Labeled Block Copolymer Micelles by High Resolution and High Sensitivity MicroSPECT/CT Imaging, Mol. Pharmaceutics, 2009, 6(2) p: 581–592.

      15. Jung, H., et al., Impact of Hapten Presentation on Antibody Binding at Lipid Membrane Interfaces, Biophysical Journal, 2008, 94(8), p: 3094-3103.

      16.Peters, M., et al., PEGylating poly(p-phenylene vinylene)-based bioimaging nanoprobes, Journal of Colloid and Interface Science, 2021, 581B, P. 566-575.

           17.Deng, M, et al., pH-Triggered Copper-Free Click Reaction-Mediated Micelle Aggregation for Enhanced Tumor Retention and Elevated Immuno–Chemotherapy against Melanoma. ACS Applied Materials & Interfaces. 2021, 13(15):18033-46.

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