Maleimide PEG Acetic Acid-北京键凯科技股份有限公司,支链聚乙二醇衍生物,直链聚乙二醇衍生物

　　键凯科技提供高品质马来酰亚胺基聚乙二醇羧酸，产品取代率≥95%。

　　键凯科技生产的异双功能马来酰亚胺PEG乙酸产品通常用作两种不同化学物质的交联剂或间隔物。此异功能PEG衍生物中的PEG部分可提供水溶性、生物相容性及柔性。此产品专门应用于抗体偶联药物(ADC’s)的开发。

　　键凯科技提供MAL-PEG-CM分子量2000 Da,3500 Da, 5000 Da, 7500 Da的产品1克和10克包装。

　　键凯科技提供分装服务，需要收取分装费用，如果您需要分装为其他规格请与我们联系。

　　键凯科技同时提供其他分子量的MAL-PEG-CM衍生物产品，如你需要请与我司sales@jenkem.com联系。

　　键凯科技提供大批量生产产品及GMP级别产品，如需报价请与我们联系。
　　References:

　　1. Wu, D., et al., RGD/TAT-functionalized chitosan-graft-PEI-PEG gene nanovector for sustained delivery of NT-3 for potential application in neural regeneration, Acta biomaterialia, 2018, 72, pp.266-277.

　　2. Alibolandi, M., et al., Curcumin-entrapped MUC-1 aptamer targeted dendrimer-gold hybrid nanostructure as a theranostic system for colon adenocarcinoma, International Journal of Pharmaceutics, 2018, V. 549 (1–2), P. 67-75.

　　3. Alibolandi, M., et al., Smart AS1411-aptamer conjugated pegylated PAMAM dendrimer for the superior delivery of camptothecin to colon adenocarcinoma in vitro and in vivo. International Journal of Pharmaceutics, 2017, 519(1):352-64.

　　4. Zhao, L., et al., An intraocular drug delivery system using targeted nanocarriers attenuates retinal ganglion cell degeneration. Journal of Controlled Release, 2017.

　　5. Brinkman, A.M., et al., Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer. Biomaterials, 2016, 101:20-31.

　　6. Chen, G., et al., Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging, Biomaterials, 2015, 47 p:41-50.

　　7. Saraswathy, M., et al., Multifunctional drug nanocarriers formed by cRGD-conjugated βCD-PAMAM-PEG for targeted cancer therapy, Colloids and Surfaces B: Biointerfaces, 2015, 126, p. 590-597.

　　8. Guo, J., et al.,Theranostic Unimolecular Micelles Based on Brush-Shaped Amphiphilic Block Copolymers for Tumor-Targeted Drug Delivery and Positron Emission Tomography Imaging, ACS Appl. Mater. Interfaces, 2014, 6(24), p: 21769–21779

　　9. Guo, J., et al., Image-guided and tumor-targeted drug delivery with radiolabeled unimolecular micelles, Biomaterials, 2013, 34(33), p: 8323–8332.

　　10. Gao, X., et al., Prostate stem cell antigen-targeted nanoparticles with dual functional properties: in vivo imaging and cancer chemotherapy. Int J Nanomedicine, 2012, 7: p. 4037-51.

　　11.Babaei, M., et al., Targeted rod-shaped mesoporous silica nanoparticles for the co-delivery of camptothecin and survivin shRNA in to colon adenocarcinoma in vitro and in vivo, European Journal of Pharmaceutics and Biopharmaceutics, 2020.

　　12.Ramezani, P., et al., Targeted MMP-2 responsive chimeric polymersomes for therapy against colorectal cancer, Colloids and Surfaces B: Biointerfaces, 2020, 193, 111135.

13.Li, C, et al., Targeted Delivery of Dual Anticancer Drugs Based on Self-Assembled iRGD-Modified Soluble Drug–Polymer Pattern Conjugate Nanoparticles. ACS Applied Bio Materials. 2021, 4(2):1499-507.