t-Boc Amine PEG Succinimidyl Carboxymethyl Ester

　　键凯科技生产的异双功能t-Boc胺PEG琥珀酰亚胺基羧甲基酯产品中含有受tBoc保护的胺基团，通常用作两种不同化学物质的交联剂或间隔物。此异功能PEG衍生物中的PEG部分可提供水溶性、生物相容性及柔性。此产品专门应用于抗体偶联药物(ADC’s)的开发。

　　键凯科技提供TBOC-PEG-SCM分子量2000 Da,3500 Da, 5000 Da, 7500 Da的产品1克和5克包装。

　　键凯科技提供分装服务，需要收取分装费用，如果您需要分装为其他规格请与我们联系。

　　键凯科技同时提供其他分子量的TBOC-PEG-SCM衍生物产品，如你需要请与我司sales@jenkem.com联系。

　　键凯科技提供大批量生产产品及GMP级别产品，如需报价请与我们联系。

References:

1. Kuruvilla, S.P., et al., Effect of N-acetylgalactosamine ligand valency on targeting dendrimers to hepatic cancer cells, International journal of pharmaceutics, 2018, 545(1-2), pp.27-36.

2. Kuruvilla, S.P., et al., N-Acetylgalactosamine-Targeted Delivery of Dendrimer-Doxorubicin Conjugates Influences Doxorubicin Cytotoxicity and Metabolic Profile in Hepatic Cancer Cells, Adv. Healthcare Mater., 2017, 1601046.3.

3. Balasso, A., et al., Re-programming pullulan for targeting and controlled release of doxorubicin to the hepatocellular carcinoma cells, European Journal of Pharmaceutical Sciences, 2017.

4. Lu, J., et al., Targeted Delivery of Doxorubicin by Folic Acid-Decorated Dual Functional Nanocarrier, Mol. Pharmaceutics, 2014, 11(11), p: 4164–4178.

5. Tanwir, K., et al., Coexisting Phases in PEGylated Phosphocholine Membranes: A Model Study, Langmuir, 2012, 28(39), pp 14000–14009.

6. Zhang, Y., et al., Incorporation of a selective sigma-2 receptor ligand enhances uptake of liposomes by multiple cancer cells. Int J Nanomedicine, 2012, 7: p. 4473–4485.

7. Smolensky, E. D., et al., Magnetoluminescent Agents for Dual MRI and Time-Gated Fluorescence Imaging, European Journal of Inorganic Chemistry, 2012, (12): 2141-2147.

8. Smolensky, E. D., et al., A responsive particulate MRI contrast agent for copper(I): a cautionary tale, Dalton Trans., 2012, 41, 8039-8046.

9.Chen, Q., et al., Biodegradable nanoparticles decorated with different carbohydrates for efficient macrophage-targeted gene therapy, Journal of Controlled Release, 2020; 323:179-90.