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Hydroxyl PEG Succinimidyl Carboxymethyl Ester
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产品名称:

Hydroxyl PEG Succinimidyl Carboxymethyl Ester

产品代号:
HO-PEG5000-SCM
产品纯度:
≥ 95%
分子量:
2000 Da,3500 Da, 5000 Da, 7500 Da等
产品编号:
A5078
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产品描述

  键凯科技提供高品质羟基PEG琥珀酰亚胺羧甲基酯,产品取代率大于等于95%。

  键凯科技生产的异双功能羟基PEG琥珀酰亚胺羧甲基酯产品通常用作两种不同化学物质的交联剂或间隔物。此异功能PEG衍生物中的PEG部分可提供水溶性、生物相容性及柔性。此产品专门应用于抗体偶联药物(ADCs)的开发。

  键凯科技提供HO-PEG-SCM分子量2000 Da,3500 Da, 5000 Da, 7500 Da的产品1克和5克包装。

  键凯科技提供分装服务,需要收取分装费用,如果您需要分装为其他规格请与我们联系。

  键凯科技同时提供其他分子量的HO-PEG-SCM衍生物产品,如你需要请与我司sales@jenkem.com联系。

  键凯科技提供大批量生产产品及GMP级别产品,如需报价请与我们联系。

References:

1. Dutta, R., et al., Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice, Pharmaceutical research, 2017, 34(3):564-78.

2. Jaskula-Sztul, R., et al., Thailandepsin A-loaded and octreotide-functionalized unimolecular micelles for targeted neuroendocrine cancer therapy, Biomaterials, 2016, 91:1-0.

3. Chen, G., et al., KE108-conjugated unimolecular micelles loaded with a novel HDAC inhibitor thailandepsin-A for targeted neuroendocrine cancer therapy, Biomaterials, 2016, 97, p. 22-33.

4. Liang, K., et al., Peptide-Tunable Drug Cytotoxicity via One-Step Assembled Polymer Nanoparticles, Advanced Materials, 2014, 26(15)p: 2398–2402.

5. Xu, W., Aptamer-conjugated and doxorubicin-loaded unimolecular micelles for targeted therapy of prostate cancer, Biomaterials, 2013, 34(21) p: 5244-5253.

6. Lak, A., et al., Highly stable monodisperse PEGylated iron oxide nanoparticle aqueous suspensions: a nontoxic tracer for homogeneous magnetic bioassays, Nanoscale, 2013, 5, p: 11447-11455.

7. Xu, W., et al., Octreotide-functionalized and resveratrol-loaded unimolecular micelles for targeted neuroendocrine cancer therapy, Nanoscale, 2013, 5.20 : 9924-9933.

8.Wang, Y., et al., A pH-responsive silica–metal–organic framework hybrid nanoparticle for the delivery of hydrophilic drugs, nucleic acids, and CRISPR-Cas9 genome-editing machineries, Journal of Controlled Release, 2020.

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