PEG (Maleimide)2

　　键凯科技提供高品质双马来酰亚胺PEG产品，产品取代率≥90%。

　　键凯科技生产的双马来酰亚胺PEG是一种有选择性地与半胱氨酸侧链上的巯基反应的巯基反应性同双功能PEG衍生物。PEG(马来酰亚胺)2可在pH5.0-6.5的环境中对含硫醇分子进行硫醇PEG修饰，可与半胱氨酸侧链上的巯基进行选择性反应。键凯科技的同双功能PEG衍生物可作为交联剂广泛应用于蛋白质和肽的PEG修饰、纳米颗粒及表面改性中。与使用线性PEG修饰的微粒相比，与同双功能PEG缀合的颗粒可保证更高的载药量。

　　键凯科技提供MAL-PEG-MAL分子量2000 Da,3500 Da, 5000 Da, 7500 Da的产品1克和5克包装。

　　键凯科技提供分装服务，需要收取分装费用，如果您需要分装为其他规格请与我们联系。

　　键凯科技同时提供其他分子量的MAL-PEG-MAL衍生物产品，如你需要请与我司sales@jenkem.com联系。

　　键凯科技提供大批量生产产品及GMP级别产品，如需报价请与我们联系。

References:

1. Day, J.R., et al., The impact of functional groups of poly(ethylene glycol) macromers on the physical properties of photo-polymerized hydrogels and the local inflammatory response in the host, Acta Biomaterialia, 2018, 67, P. 42-52.

2. Ozdemir, T., et al., Bottom-up assembly of salivary gland microtissues for assessing myoepithelial cell function, Biomaterials, 2017, V. 142, P. 124-135.

3. Azam, A., et al., Type III secretion as a generalizable strategy for the production of full-length biopolymer-forming proteins, Biotechnol. Bioeng., 2015.

4. Yu, W., et al., PEGylated recombinant human interferon-ω as a long-acting antiviral agent: Structure, antiviral activity and pharmacokinetics. Antiviral Research, 2014, 108: p. 142-147.

5. Tang, L., et al., Separation and detection of bis-maleimide-polyethylene glycol and mono-maleimide-polyethylene glycol by reversed-phase high pressure liquid chromatography, Journal of Chromatography A, 2012, 1246, p: 117–122.

6. Soon, A.S.C., Exploiting fibrin knob:hole interactions for the control of fibrin polymerization, Georgia Institute of Technology, 2011.

7. Soon, A.S.C., et al., Modulation of fibrin matrix properties via knob:hole affinity interactions using peptide–PEG conjugates, Biomaterials, 2011, 32:19, P. 4406-4414.