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Methoxy PEG Propionaldehyde
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产品名称:

Methoxy PEG Propionaldehyde

产品代号:
M-ALD-20K
产品纯度:
≥ 95%
分子量:
5000 Da-40000 Da,等
产品编号:
A3001
没有此类产品
产品描述

  甲氧基聚乙二醇丙醛是一个N-端氨基反应的聚乙二醇活性衍生物。可对蛋白、多肽或其他生物仿制品中的氨基进行定点修饰,条件温和在PH=5-8还原剂存在下即可进行。

  键凯科技提供M-ALD分子量的5000 Da,10000 Da,20000 Da,30000 Da,40000 Da 的产品1克和10克包装。

  键凯科技提供分装服务,需要收取分装费用,如果您需要分装为其他规格请与我们联系。

  键凯科技同时提供其他分子量的M-ALD产品,如你需要请与我司sales@jenkem.com联系。

  键凯科技提供大批量生产产品及GMP级别产品,如需报价请与我们联系.

References:

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  4. Cheng, Y., et al., Doxorubicin Loaded Tumor-Triggered Targeting Ammonium Bicarbonate Liposomes for Tumor-Specific Drug Delivery, Colloids and Surfaces B: Biointerfaces, 2019.
  5. Gertler, A., et al., Pegylated Human Leptin D23L Mutant–Preparation and Biological Activity In Vitro and in Vivo in Male ob/ob Mice, Endocrinology, 2019.
  6. Liu, S., et al., Acetazolamide‐Loaded pH‐Responsive Nanoparticles Alleviating Tumor Acidosis to Enhance Chemotherapy Effects, Macromolecular bioscience, 2019, 9(2).
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  8. Behi, J., et al., Optimization of PEGylation reaction time and molar ratio of rhG-CSF toward increasing bioactive potency of monoPEGylated protein, International Journal of Biological Macromolecules, 2018, V. 109, P. 888-895.
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  10. Zhao, Y.Z., et al., PEGylation with the thiosuccinimido butylamine linker significantly increases the stability of haloalkane dehalogenase DhaA, Journal of Biotechnology, 2017.
  11. Mejia‐Manzano, L.A., et al., Recovery of PEGylated and native lysozyme using an in situ aqueous two‐phase system directly from the PEGylation reaction, Journal of Chemical Technology and Biotechnology, 2017.
  12. Zhang, L., et al., Suppression for lung metastasis by depletion of collagen I and lysyl oxidase via losartan assisted with paclitaxel-loaded pH-sensitive liposomes in breast cancer, Drug Delivery, 2016.
  13. Mayolo‐Deloisa, K., et al.,  PEGylated protein separation using different hydrophobic interaction supports: Conventional and monolithic supports. Biotechnology progress, 2016.
  14. Zhang, Y., et al., Co-delivery of doxorubicin and curcumin by pH-sensitive prodrug nanoparticle for combination therapy of cancer. Scientific Reports, 2016, 6:21225.
  15. Mata-Gomez, M.A., et al., Modelling of electrokinetic phenomena for capture of PEGylated ribonuclease A in a microdevice with insulating structures, Biomicrofluidics, 2016, 10(3): 033106.
  16. Abbasi, S., et al., Design and cell cytotoxicity assessment of palmitoylated polyethylene glycol-grafted chitosan as nanomicelle carrier for paclitaxelJ. Appl. Polym. Sci., 2015133, 43233.
  17. Mayolo-Deloisa, K., et al., Aldehyde PEGylation of laccase from Trametes versicolor in route to increase its stability: effect on enzymatic activity, Journal of Molecular Recognition, 2015, 28(3): 173-179.
  18. Wu, L., et al., N-Terminal Modification with Pseudo-Bifunctional PEG-Hexadecane Markedly Improves the Pharmacological Profile of Human Growth Hormone, Molecular Pharmaceutics, 2015.
  19. Zhang, L., et al., High Tumor Penetration of Paclitaxel Loaded pH Sensitive Cleavable Liposomes by Depletion of Tumor Collagen I in Breast Cancer,  ACS Applied Materials & Interfaces, 2015.
  20. Mata-Gómez, M. A., et al., Dielectrophoretic behavior of PEGylated RNase A inside a microchannel with diamond-shaped insulating posts. Electrophoresis, 2015.
  21. Parikh, H., et al., Improving Properties of Recombinant SsoPox by Site-Specific Pegylation, Protein and Peptide Letters, 2015, 22:12.
  22. Tiwari, D., et al., Efficient Purification of rhG-CSF and its PEGylated Forms and Evaluation for In Vitro Activities, Protein and Peptide Letters, 2015, 22:10, pp. 877-884(8).
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  24. Wu, L., Phenyl Amide Linker Improves the Pharmacokinetics and Pharmacodynamics of N-Terminally Mono-PEGylated Human Growth Hormone, Mol. Pharmaceutics, 2014, 11(9), p: 3080–3089.
  25. Xue, X., et al., Heat treatment increases the bioactivity of C-terminally PEGylated staphylokinase. Process Biochemistry, 2014. 49(7): p. 1092-1096.
  26. Pink, A., et al., Purification, characterization and plasma half-life of PEGylated soluble recombinant non-HA-binding CD44, BioDrugs, 2014, 28(4) p:393-402.
  27. Yu, W., et al., PEGylated recombinant human interferon-ω as a long-acting antiviral agent: Structure, antiviral activity and pharmacokinetics. Antiviral Research, 2014, 108: p. 142-147.
  28. Li, R., et al., Preparation and Characterization of Biological Non-toxic Hybrid Nanoparticles Based on Lactide and Poly(ethylene glycol) Loading Docetaxel for Anticancer Drug Delivery, Chinese Journal of Chemical Engineering, 2014, 22:11–12, P. 1357-1362.
  29. Martinez, A.H., et al., Chemical grafting of Sepharose 6B and its use in the purification of PEGylated RNase A, Separation and Purification Technology, 2014, 136, P. 190-198.
  30. Mu Q, et al., Molecular Insight into the Steric Shielding Effect of PEG on the Conjugated Staphylokinase: Biochemical Characterization and Molecular Dynamics Simulation, PLoS ONE, 2013, 8(7): e68559.
  31. Wu, L., et al., N-terminal mono-PEGylation of growth hormone antagonist: Correlation of PEG size and pharmacodynamic behavior, International journal of pharmaceutics, 2013, 453.2 : 533-540.
  32. Tian, H., et al., PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation, Journal of Pharmacy and Pharmacology, 2013, 65.1 : 53-63.
  33. Galindo‐López, M., et al., Practical non‐chromatography strategies for the potential separation of PEGylated RNase A conjugates, Journal of Chemical Technology and Biotechnology, 2013, 88.1 : 49-54.
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  35. Niv-Spector, L., Preparation and characterization of mouse IL-22 and its four single-amino-acid muteins that act as IL-22 receptor-1 antagonists, Protein Engineering, Design & Selection, 2012, 25(8). p:397-404.
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  39. Shpilman, M., et al., Development and Characterization of High Affinity Leptins and Leptin Antagonists, The Journal of Biological Chemistry, 2011, 286(6), p: 4429 –4442.
  40. Top, A., et al., Conformational and Aggregation Properties of a PEGylated Alanine-Rich Polypeptide, Biomacromolecules, 2011, 12(6), pp 2184–2192.
  41. Wang, J., et al., Kinetic and stoichiometric analysis of the modification process for N-terminal PEGylation of staphylokinase, Analytical Biochemistry, 2011, 412: 1, P. 114-116.
  42. Gonzalez-Valdez, J., et al., Potential application of aqueous two-phase systems for the fractionation of RNase A and α-Lactalbumin from their PEGylated conjugates, J. Chem. Technol. Biotechnol., 2011, 86: 26–33.
  43. Wang, Y-J., et al., PEGylation markedly enhances the in vivo potency of recombinant human non-glycosylated erythropoietin: A comparison with glycosylated erythropoietin, Journal of Controlled Release, 2010, 145:3, p. 306-313.
  44. Elinav, E., et al., Pegylated Leptin Antagonist Is a Potent Orexigenic Agent: Preparation and Mechanism of Activity, Endocrinology, 2009, 150(7), 3083–3091.
  45. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000420/WC500025941.pdf.
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