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Methoxy PEG Succinimidyl Hexanoate
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产品名称:

Methoxy PEG Succinimidyl Hexanoate

产品代号:
M-SHA-5000
产品纯度:
≥ 95%
分子量:
5000 Da-20000 Da,等
产品编号:
A3146
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产品描述

  甲氧基丁酸琥珀酰亚胺酯在室温下,PH=7-8环境中能与赖氨酸或其他分子中的氨基反应,例如可以对重组人促红素生物仿制品等中的活性组分中的氨基进行聚乙二醇化。

  M-SHA比M-SCM具有更长的水解半衰期,稳定性较好。

  键凯科技提供M-SHA 分子量的5000 Da,20000 Da的产品1克和10克包装。

  键凯科技提供分装服务,需要收取分装费用,如果您需要分装为其他规格请与我们联系。

  键凯科技同时提供其他分子量的M-SHA产品,如你需要请与我司sales@jenkem.com联系。

  键凯科技提供大批量生产产品及GMP级别产品,如需报价请与我们联系。

References:

1. Vaillard, V.A., et al., mPEG–NHS carbonates: Effect of alkyl spacers on the reactivity: Kinetic and mechanistic insights, Journal of Applied Polymer Science, 2019, 136(5):47028.

2. Ma, S.S., et al., The pharmacokinetic and pharmacodynamic properties of site-specific pegylated genetically modified recombinant human interleukin-11 in normal and thrombocytopenic monkeys, European Journal of Pharmaceutics and Biopharmaceutics, 2017.

3. Zhao, Y.Z., et al., PEGylation with the thiosuccinimido butylamine linker significantly increases the stability of haloalkane dehalogenase DhaA, Journal of Biotechnology, 2017.

4. Lee, K., et al., Enhanced accumulation of theranostic nanoparticles in brain tumor by external magnetic field mediated in situ clustering of magnetic nanoparticles, Journal of Industrial and Engineering Chemistry, 2017.

5. Wan, X., et al., Effect of protein immunogenicity and PEG size and branching on the anti-PEG immune response to PEGylated proteins, Process Biochemistry, 2017, 52:183-91.

6. Fahrlander E., et al., PEGylated human serum albumin (HSA) nanoparticles: preparation, characterization and quantification of the PEGylation extent, Nanotechnology, 2015, 26(14):145103.

7. Zhang, J., et al., Magnetic Targeting of Novel Heparinized Iron Oxide Nanoparticles Evaluated in a 9L-glioma Mouse Model, Pharmaceutical Research, 2014, 31:3, pp 579-592.

8. Peng, F., et al., PEGylation of G-CSF in organic solvent markedly increase the efficacy and reactivity through protein unfolding, hydrolysis inhibition and solvent effect. Journal of Biotechnology, 2014, 170: p. 42-49.

9. Mingji Jin, et al, Preparation of pegylated lumbrokinase and an evaluation of its thrombolytic activity both in vitro and in vivo, Acta Pharmaceutica Sinica B, 2013, 3(2) p: 123-129.

10. Zhang, J., et al., Long-Circulating Heparin-Functionalized Magnetic Nanoparticles for Potential Application as a Protein Drug Delivery Platform, Molecular Pharmaceutics, 2013, 10(10), 3892-3902.

11. Jun Wang, et al., An oriented adsorption strategy for efficient solid phase PEGylation of recombinant staphylokinase by immobilized metal-ion affinity chromatography, Process Biochemistry, 2012, 47, 1,  p: 106-112.

12. Liu, S.. et al., Mono-PEGylation of ribonuclease A: High PEGylation efficiency by thiolation with small molecular weight reagent, Process Biochemistry, 2012, 47(9),  p: 1364-1370.

13.  Peng, F., et al., PEGylation of Proteins in Organic Solution: A Case Study for Interferon beta-1b, Bioconjugate Chem., 2012, 23 (9), 1812-1820.

14. Beibei, H., Design, Preparation and in vitro Bioactivity of Mono-PEGylated Recombinant Hirudin, Chin. J. Chem. Eng., 2007, 15(6) 775—780.

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